Clinicopharmacological Study on Probucol (2)

The Effect of Probucol on Diabetic Nephropathy

D iabetic nephropathy is a major complication of diabetes. In the early stage, microalbuminuria is observed and followed by massive proteinuria. In the advanced stage, renal function decreases and uremia occurs. If nephropathy progresses, hemodialysis has to be initiated. Accordingly, suppressing the progression of diabetic nephropathy is important and urgent for the patient’s quality of life. ...

Effects of probucol on angiotensin II-induced BMP-2 expression in human umbilical vein endothelial cells.

Bone morphogenetic protein-2 (BMP-2) participates significantly in vascular development and pathophysiological processes. Angiotensin II (AngII) has been demonstrated to be critical in the initiation and progression of atherosclerosis. However, the effects of AngII on BMP-2 expression and of probucol on the AngII-induced BMP-2 expression in human umbilical vein endothelial cells (HUVECs) are un...

Effects of probucol on vascular remodeling after coronary angioplasty. Multivitamins and Protocol Study Group.

BACKGROUND We have shown that probucol reduces restenosis after balloon angioplasty. Whether probucol acted via prevention of neointimal formation or improvement in vascular remodeling could not be addressed by angiography and required the use of intravascular ultrasound (IVUS). METHODS AND RESULTS Beginning 30 days before angioplasty, 317 patients were randomly assigned to receive probucol, ...

Probucol in Albuminuric Type 2 Diabetes Mellitus Patients on Renin–Angiotensin System Blockade

a study on construction of iranian life tables: the case study of modified brass logit system

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